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Sreeramulu, J.
- Synthesis and Characterization of new Dithiocarbamate Complexes
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Authors
Affiliations
1 Dept. of Chemistry, Sri Krishnadevaraya University, Anantapur, A.P, IN
1 Dept. of Chemistry, Sri Krishnadevaraya University, Anantapur, A.P, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 4 (2013), Pagination: 323-330Abstract
New series of bidentate ligands such as dithocarbamates of 2-Amino-3-Methyl pyridine (2A3MPDTC) and 2- Amino-4-Methyl pyridine (2A4MPDTC) were prepared by new synthetic methods as their sodium salts. In the reaction of Copper Chloride and Cobalt Chloride with 2A3MPDTC and 2A4MPDTC the corresponding complexes were prepared. The complexes were characterized by elemental analysis, IR, 1H NMR, UV, ESR and TGA - DTA. These metal complexes play a good activity against E. coli and Basillus subtilis. The investigations revealed that the complexes are better anti-bacterial agents than the Ligands.Keywords
2–amino–3–methyl Pyridine, 2–amino–4–methyl Pyridine, Copper Chloride, Cobalt Chloride, Dithiocarbamates, Synthesis, Characterization, Anti Bacterial Activity
References
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- Development and Validation of RP-HPLC Method for Estimation of Impurities of Cefprozil in its Powder for Oral Suspension Dosage Form Using Sub 2-μm Column
Abstract Views :189 |
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Authors
Affiliations
1 Department of Chemistry, S.K. University, Anantapur 515003, IN
2 Hospira Healthcare India Pvt. Ltd., SIPCOT Industrial Park, Irungattukottai, Sriperumbudur, Kancheepuram District, Tamilnadu 602105, IN
3 Orchid Chemicals and Pharmaceuticals Ltd, SIPCOT Industrial Park, Irungattukottai, Sriperumbudur, Kancheepuram District, Tamilnadu 602105, IN
1 Department of Chemistry, S.K. University, Anantapur 515003, IN
2 Hospira Healthcare India Pvt. Ltd., SIPCOT Industrial Park, Irungattukottai, Sriperumbudur, Kancheepuram District, Tamilnadu 602105, IN
3 Orchid Chemicals and Pharmaceuticals Ltd, SIPCOT Industrial Park, Irungattukottai, Sriperumbudur, Kancheepuram District, Tamilnadu 602105, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 5 (2011), Pagination: 810-814Abstract
A reversed-phase high-performance liquid chromatographic method for separation and quantification of impurities of Cefprozil powder for oral suspension dosage form has been developed and validated. Chromatography was performed on a 100 x 4.6 mm, 1.8-μm particle, C18 column with mobile phase-A, 0.23 % Ammonium dihydrogen orthophosphate in water and mobile phase-B, 80 : 20 (v/v) Methanol - mobile phase-A by gradient elution. The system was operated at 0.6 mL min-1 mobile phase flow rate and the column thermostat was maintained at 25°C. UV detection was performed at 290 nm. Forced degradation studies were conducted on Drug product using ICH stress study guidelines to demonstrate the specificity and stability-indicating nature of the method. The method was validated for precision, accuracy, linearity, specificity and sensitivity in accordance with ICH guidelines. LOD and LOQ for individual impurities were below 0.014 and 0.037 % (w/w) respectively. Validation revealed the method is specific, precise, accurate, linear, robust and reproducible.Keywords
RP-HPLC, Cefprozil, Validation, Forced Degradation.- Stability Indicating Fast LC Method for the Estimation of Impurities in Cephalexin for Oral Suspension
Abstract Views :169 |
PDF Views:0
Authors
Affiliations
1 Department of Chemistry, S.K. University, Anantapur-515003, IN
2 Hospira Healthcare India Pvt. Ltd., SIPCOT Industrial Park, Irungattukottai, Sriperumbudur-602105, Kancheepuram District, Tamilnadu, IN
3 Orchid Chemicals and Pharmaceuticals Ltd, SIPCOT Industrial Park, Irungattukottai, Sriperumbudur-602105, Kancheepuram District, Tamilnadu, IN
1 Department of Chemistry, S.K. University, Anantapur-515003, IN
2 Hospira Healthcare India Pvt. Ltd., SIPCOT Industrial Park, Irungattukottai, Sriperumbudur-602105, Kancheepuram District, Tamilnadu, IN
3 Orchid Chemicals and Pharmaceuticals Ltd, SIPCOT Industrial Park, Irungattukottai, Sriperumbudur-602105, Kancheepuram District, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 4 (2010), Pagination: 1090-1094Abstract
A fast, stability-indicating reversed phase liquid chromatographic method has been developed and subsequently validated for the estimation of impurities of Cephalexin. The developed method utilizes the chemistry of sub 2-μm C-18 column and mobile phase consisting of Potassium dihydrogen phosphate buffer-acetonitrile with gradient elution, at a flow rate of 1.0 mL per minute. The detection was carried out at 254 nm. As there are no simple Fast LC methods reported for the estimation of Impurities/degradants of Cephalexin in Pharmaceutical formulations, the current method was developed and validated. The method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantification, ruggedness and robustness. This method has been successfully applied to pharmaceutical formulation and no interference from the excipients used the powder for suspension was found. As the proposed method could effectively separate the drug from its degradants/impurities, it can be employed as stability-indicating method for the determination of instability of the drug in bulk and pharmaceutical formulations.Keywords
Liquid Chromatography, Drug Product, Degradants, Stability Indicating.- Stability Indicating Fast LC Method for the Estimation of Impurities of Pantoprazole in Tablet Dosage Forms
Abstract Views :151 |
PDF Views:0
Authors
Affiliations
1 Department of Chemistry, S.K. University, Anantapur-515003, IN
2 Orchid Chemicals and Pharmaceuticals Ltd, SIPCOT Industrial Park, Irungattukottai, Sriperumbudur-602105, Kancheepuram District, Tamilnadu, IN
1 Department of Chemistry, S.K. University, Anantapur-515003, IN
2 Orchid Chemicals and Pharmaceuticals Ltd, SIPCOT Industrial Park, Irungattukottai, Sriperumbudur-602105, Kancheepuram District, Tamilnadu, IN